The MT8221B, like other high performance instruments, is susceptible to ESD (electrostatic discharge) damage. Coaxial cables and antennas often build up a static charge, which (if allowed to discharge by connecting directly to the MT8221B without discharging the static charge) may damage the MT8221B input circuitry. MT8221B operators must be aware of the potential for ESD damage and take all necessary precautions.

Operators should exercise practices outlined within industry standards such as JEDEC‑625 (EIA‑625), MIL‑HDBK‑263, and MIL‑STD‑1686, which pertain to ESD and ESDS devices, equipment, and practices. Because these apply to the MT8221B, Anritsu Company recommends that any static charges that may be present be dissipated before connecting coaxial cables or antennas to the MT8221B. This may be as simple as temporarily attaching a short or load device to the cable or antenna prior to attaching to the MT8221B. Remember that the operator may also carry a static charge that can cause damage. Following the practices outlined in the above standards ensures a safe environment for both personnel and equipment.