The MT8220T loads factory calibration data during start‑up, eliminating the need for daily calibration checks. In W-CDMA mode, an additional automatic calibration is performed as the internal temperature of the MT8220T changes (to ensure the best possible measurement results). The Cable and Antenna Analyzer mode requires calibration standards for OPEN, SHORT, and LOAD (OSL), which are sold separately.

Although the MT8220T does not require daily field calibration, Anritsu recommends an annual calibration and performance verification by local Anritsu service centers. Contact information for Anritsu Service Centers is available at http://www.anritsu.com/contact-us.