This chapter provides general measurement setup fundamental concepts, requirements, and options for different types of measurements. Specifically, this chapter describes channels, traces, limit lines, external analog input/output, averaging, and smoothing and organizes their configuration in the same hierarchy. Channel is the highest level configuration with up to 16 channels possible, each with a different frequency range, power level, IF bandwidth, and RF calibration. On a per-channel basis, traces are lower level concepts that represent a data group with up to 16 traces per channel. Limit lines are described with setup tasks and test functionality. External analog input/output is described with setup issues, range, functions, resolution, and accuracy. A description of averaging and smoothing with their available functions and the effects on measurements conclude the chapter.